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Fisofine Cream: Effective Treatment for Anal Fissures

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Dr. Jameel - MBBS, MCPS (Family Med)

Dr. Jameel, a compassionate family physician, simplifies medical information through easy-to-understand blogs. His holistic approach promotes healthier living, and he's actively engaged in local health initiatives. Join him on your journey to better health.

Fisofine cream

Fisofine cream is a specialized topical treatment specifically designed to alleviate the discomfort associated with anal fissures. Comprising active ingredients such as nifedipine and lidocaine, this cream aims to provide relief and promote healing for individuals experiencing anal fissures.

What are Anal Fissures?

Anal fissures are small tears or cuts in the lining of the anal canal, often causing pain, discomfort and bleeding during bowel movements. Fisofine cream is formulated to target this condition and offer soothing effects.

Components of Fisofine Cream

Fisofine cream has two components which are:

1. Nifedipine (1.5% w/w)

A calcium channel blocker medication that relaxes the anal sphincter muscles, aiding in healing.

2. Lidocaine (0.3 % w/w)

A local anesthetic that helps in reducing pain and discomfort.

Working Mechanism of Fisofine Cream

It primarily acts in following ways:

  • Nifedipine relaxes the muscles, allowing better blood flow and promoting healing.
  • Lidocaine numbs the area, providing relief from pain and discomfort.

Uses of Fisofine Cream

It is specifically tailored for the treatment of anal fissures. It also addresses the discomfort associated with this condition. Main uses of fisofine are:

    • Alleviating pain and discomfort caused by anal fissures.
    • Aiding in the healing process of anal tears and cuts.

Benefits of Using Fisofine Cream

Utilizing this cream for anal fissures offers several advantages:

    • Relieves pain and discomfort during bowel movements.
    • Helps in healing the anal fissures.
    • Reduces inflammation and irritation in the affected area.

Who Can Use Fisofine Cream?

It is typically safe for adults experiencing anal fissures, but it’s advisable to seek medical advice before use, especially for specific health conditions or allergies.

How to Use Fisofine Cream?How to use Fisofine cream

Proper application of the cream is essential for maximizing its effectiveness and ensuring relief from anal fissure symptoms. Steps in applying the cream are:

    • Wash the affected area gently and pat it dry.
    • Apply a small amount of Fisofine cream to the affected area using clean hands.
    • Gently massage the cream into the skin around the anus.
    • Use it as directed by a healthcare professional, usually after bowel movements and before bedtime.

Possible Side Effects

While Fisofine cream is generally safe, it can cause following side effects:

    • Mild irritation or itching in some cases (rare)
    • Allergic reactions to specific ingredients (less common)


Precautionary measures that must be followed are:

  • Patch Test: Check for skin reactions before widespread use.
  • Consultation: Seek advice from a healthcare professional before starting.
  • Dosage/Usage: Follow recommended dosage and application instructions strictly.
  • Discontinue if needed: Stop use if adverse reactions occur and seek medical help.

Contraindications of Fisofine Cream

It should be avoided or used cautiously in following situations:

  1. Allergies: Avoid if allergic to nifedipine, lidocaine, or any cream ingredient.
  2. Pregnancy/Breastfeeding: Consult a healthcare provider before using during pregnancy or breastfeeding.
  3. Children: Seek guidance before using on children.
  4. Open Wounds/Infections: Avoid applying to open wounds or infected areas.
  5. Medication Interactions: Inform your doctor about other medications to prevent interactions.


1. What is Fisofine Cream used for?

It is specifically formulated to treat anal fissures. It helps in relieving pain, reducing discomfort, and promoting healing in the affected area.

2. How does Fisofine Cream work?

It contains nifedipine, which relaxes the muscles in the anal area, improving blood flow and aiding in healing. It also includes lidocaine, a local anesthetic that helps in reducing pain and discomfort.

3. Is Fisofine Cream safe for everyone to use?

It is generally safe for adults when used as directed. However, individuals with certain health conditions like heart issues or allergies to its components should consult a healthcare professional before use.

4. How should I apply it?

Clean the affected area gently, then apply a small amount of cream using clean hands. Gently massage it into the skin around the anus as directed by your healthcare provider.

5. Are there any side effects ?

While uncommon, some individuals might experience mild irritation, itching or allergic reactions to Fisofine cream.

For any further query feel free to contact us at

Bottom Line

Fisofine cream stands as a specialized topical solution designed to alleviate the discomfort associated with anal fissures. By combining the therapeutic effects of nifedipine and lidocaine, it aims to relieve pain, reduce inflammation, and promote healing in individuals experiencing anal fissures.


Content on this site is written with thorough research and keeping in mind the latest guidelines. However, no content on this site should substitute professional consultation.

Picture of Dr. Jameel

Dr. Jameel

Dr Jameel is a practicing family physician. He writes easy to understand medical blogs to create health awareness and help people to live a healthier life.

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